Linker Length in Biotinylated Probes is Key to Identifying Target Proteins for Anticancer Natural Product OSW-1

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January 10, 2025

?Graduate students Myat Nyein Khine, Naho Isogai (former student), and Tomoya Takeshita (former student), led by Professor Kaori Sakurai from the Division of Biotechnology and Life Science,? Institute of Engineering at Tokyo University of Agriculture and Technology, have developed an optimized biotinylated probe to study OSW-1, a potent anticancer natural product. In this study, they demonstrated that the length of the linker in the biotinylated probe of OSW-1 is crucial for effectively capturing the target proteins (Figure 1).
?This study was supported by the JSPS ACBI program, KAKENHI (18K05331 and